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Information on Linear Porokeratosis
Linear Porokeratosis is a rare type of porokeratosis and characterized by chronic, unilateral extremities lesions. Linear porokeratosis generally develops in childhood or can grow in adult life. Lesion has abnormal keratinization characterized by a healed or atrophic center surrounded by keratin limits, with histopathologic changes that include compact column of parakeratotic cells in small epidermal invaginations, constituting the cornoid lamella. Occasionally there is a family history of linear porokeratosis or another kind of porokeratosis such as disseminated superficial actinic porokeratosis (DSAP), suggesting a genetic predisposition.
Linear porokeratosis affect men twice as often as women. Many risk factors for the progress of porokeratosis have been identified; these factors comprise genetic inheritance, ultraviolet radiation, and immunosuppressant. Immunosuppressant related with porokeratosis may be secondary to a disease process such as HIV infection or lymphoma or an iatrogenic suppression such as with immune-modulating drugs used to prevent organ transplant rejection or to treat autoimmune diseases. Symptoms of linear porokeratosis can develop within a linear porokeratosis patch.
Linear Porokeratosis may be also a basal or squamous cell carcinoma, and is more expected to arise in older adults. If a lump or sore appears within a porokeratosis lesion, arrange for it to be reviewed by your dermatologist. It may need a biopsy or cutting out. There is no cure for linear porokeratosis and treatment is normally disappointing. Topical 5-fluorouracil can induce remission in all forms of porokeratosis. Treatment must be continued until a brisk inflammatory reaction is obtained. Calcipotriol and tacalcitol have been shown to be helpful treatment of linear porokeratosis.
Sun protection is very important as exposure to ultraviolet radiation may result in the development of skin cancer lesions within the linear porokeratosis. Cryotherapy is also used in Linear porokeratosis heal. Cryotherapy refers to a treatment in which surface skin lesions are frozen. It is a minimally invasive way of inducing resolution for huge numbers of lesions. Cryotherapy stings and may be painful, at the time and for a variable period afterwards. There may be instant swelling and redness. Surgical treatment is essential for porokeratosis lesions that have undergone malignant transformation.
About the Author
Juliet Cohen writes articles for skin care tips. She also writes articles for haircut styles and beauty tips.
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